Detection of an uncorrelated component in a multi-channel acoustic signal is disclosed. The herbal pharmaceutical compositions are effective in preventing patients from developing or treating patients with cardiovascular diseases, which include, but are not limited to, hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease, and cardiomyopathies. The seal extends from the seal base as a thin, elastically deformable ring around a circumference of the seal base, and presses against a surface of the coupling member to provide a seal between the connector body and coupling member. A gland seal portion makes a seal between the elastomeric diaphragm and sealing structure and a mating part.