The present invention relates to novel Fused Tetracycle Derivatives of Formula : and pharmaceutically acceptable salts thereof, wherein A, A\u2032, B, G, R1, U, V, W, W\u2032, X, X\u2032, Y and Y\u2032 are as defined herein. The surgical forceps include in their body a channel for receiving a flexible tube having a wire within it. Reference multi-band image vectors are created and those vectors are processed in a block-wise form to obtain custom orthonormal representation matrices. Multiple filamentation regulatory pathways have been discovered, however the downstream effectors of these regulatory pathways remain unknown.