An optical isomer separating filler wherein a polysaccharide derivative is chemically bonded onto a support. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 4:and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. A first dielectric film is formed from silicon oxide on the amorphous silicon film. A message may include one or more snapshots, attributes for the message, andor access control information for the message. The pumped storage provides flow and head to generate electric power through the turbine generator.