Provided is an electronic device including: a base; a panel; a support for supporting the panel with respect to the base; and a vibrator for causing the panel to vibrate at a given frequency. In the method web passed to the reel is cut, and the surface layers of the reel are bound by a pressing device which is in contact with the surface of the rotating reel and has a press member forming a nip with the peripheral surface of the reel and rotating substantially at the same surface speed therewith. In the thus obtained metal base substrate, a glass layer composed of Cu\u2014Ba\u2014Si based glass with a thickness of about 1 \u03bcm to about 5 \u03bcm is formed between the metal substrate and the low-temperature sintering ceramic layer. A second face of the wafer may be grinded such that the electrode metal layer in the hole may be exposed through the second face. The sealing member includes a first frit and a second frit which melts substantially easier than the first frit upon irradiation of a laser or infrared beam thereto. The invention also relates to a method of identifying agents which can bind to GPR-9-6 and inhibit the binding of a ligand andor modulate a function of GPR-9-6.