The present invention provides methods of identifying agents that affect the cleavage of amyloid- precursor protein and related vectors, cells and kits, as well as agents identified by the method. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and diagnostic agents when said invention is used in conjunction with the appropriate device. When the spigot is in the inner dispensing position water can be dispensed into a container positioned in the dispensing cavity. Each actuating member is connectable by a respective Bowden cable to one of the selectors of the gearbox and extends and retracts the cable in response to rotation of the actuating member about the axle.