The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:wherein A, X, Y R1, R2, R3, R4, m and n are as described herein. The device comprising first and second terminals which, in use, are connected to components in a system for controlling mechanical forces. The sliding bases move on rails with hardly any frictional resistance. The panels are interconnected at a sealed first end. Based on the preassignment and the n-dimensional memory, the hardware circuit matches the longest prefix key stored in the prefix search engines by comparing all prefix search engines in parallel.