A projection data rebinning device for nearest-neighbor rebinning in Positron Emission Tomography using on-line 3D axial LOR-to-bin mapping. The present invention provides for nucleic acids and protein for use in methods and compositions for the diagnosis of disease and identification of small molecule therapeutics for treatment of such disease, in particular of proteinuria associated with kidney disease. In this fashion, the neck and head of the patient is immobilized via the positional support provided by the lower ring and without the need for screws mounted to the skull. Some embodiments respond to how quickly the user changes the amount of pressure applied. Additional second structures are created on receipt of additional continuous queries which use the new function, but all second structures contain the same path.