A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The hardware and FIFO signal modifications make the FIFO-DMA interface immune to deadlock conditions and generation of spurious interrupt events in the process of initiating burst transfers. The projectionimage formation optical system includes a zoom type transfer lens system having a first zoom lens and a second zoom lens. With a first working voltage applied between the moveable and the fixed driving stages, moving of the driving stages’ sensing direction towards gravity at a first critical angle will cause moveable driving stages to collapse and touch the fixed driving stage on the substrate and thus turn on the MEMS G-switch. At least one end of the slot includes means for preventing lateral widening of the dispensed material. The support members are disposed along the inner peripheral wall of the lens barrel and support part of the spherical surface of the spherical bodies.