The present invention provides an application method of a Cr-plated mandrel bar repeatedly used in mandrel mill rolling by the Mannesmann tube making process. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifying such conditions. The mold halves and the scalping gate are each formed of a copper alloy having a thermal conductivity of not less than 120 W and a hardness of not less than 180 HB. A context is created for the native code and the context is either transmitted to the target processor or stored in a memory location such that the target processor may retrieve the context. A plurality of via contacts are arranged at regular intervals, each of which is not larger than a given value, in an effective diffusion region of voids included in the lower interconnection, when the width or volume of the lower interconnection exceeds a given value.