Methods and devices for the regulation of gene expression by cells via the application of fields generated by specific and selective electric and electromagnetic signals so as to target diseased or injured tissue for treatment. In one embodiment, a 3D memory device can include at least two sources; at least two memory arrays respectively formed over and coupled to the at least two sources; and a source conductor electrically respectively coupled to the at least two sources using source contacts adjacent one or more edges of the source. Since the normal or abnormal state of the electric devices is reported to the driver, the driver can easily know which part of an automobile has a malfunction while driving the automobile. An arcuate sheath having a cutter is used to remove tissue from the inner annulus of the disc. A rear baffle is applied to a first conformal portion surface of the conformal portion of the loudspeaker frame.