Peptides able to inhibit or activate the translocation or function of \u03b4PKC are identified. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage. The lamination tool of the present invention uses compressed gas to press the lead frame against the adhesive film. The anal irrigation system comprises an anal probe; a reservoir for holding an irrigation liquid ; a pump mechanism for pumping a fluid into the reservoir; and a liquid tube connecting the reservoir with the anal probe. Optionally, the bottle comprises an insulating internal chamber adapted to insulate the liquid housed therein, keeping the liquid at a constant temperature for a period of time.