Semiconductor devices with reduced substrate defects and methods of manufacture are disclosed. The article also includes a fluid flow barrier disposed local to the passive component site and spaced apart from the active component site. of plastics material having a pore size of 10 microns or greater, through which the applied liquid sample must pass en route to the porous carrier material, the labelled specific binding reagent being freely soluble or dispersible in any liquid sample which enters the macroporous body. In addition, new security domains may be created automatically based on security requirements of newly installed applications. The select device is activated by applying voltage to the second portion of first polysilicon layer. A joint pivotally attaches the platform to the bracket and includes a pair of plates and a post with a second ball bearing and a screw boss.