Deep submicron wells of MOS transistors, implemented over an ungrounded well, exhibit two modes of operation: a current sink mode and a current source mode. An IL-1\u03b2 binding antibody or IL-1\u03b2 binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO:28, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1\u03b2 binding polypeptide is provided. The finishes are applied to a substrate to produce a finish that may be modified following application.