The present invention relates to a multi-functional nucleic acid-based anti-cancer drug in which the anti-cancer drug is physically bound to a linear nucleic acid having a thiol group at 5\u2032 terminal thereof and then gold nanoparticles and aptamers are chemically bound. Knowing the system’s fuel chemistry, the fuel calorific value, the fuel flow and the thermal performance associated with the thermal system may then be determined in essentially real time. , as measured according to the ASTM D1662 standard, and the elementary sulfur mass content, as measured according to the ASTM D5185 standard, SactiveS, of said lubricating composition, is less than 0.