An Electrochemical biosensor readout meter which can do selectively quantitative analysis of sample of living body such as blood sugar, cholesterol and other elements in blood is disclosed. The debug monitor supports the performance of one or more debug operations on the programmable core model during simulation thereof. There may also be a second pair of electrodes separated by the membrane for injecting the stimulus current such that the injecting and monitoring functions are separated. An imaging device is directed towards the marker portions and includes an array of light-detecting elements for sensing light emitted from the marker portions to generate image data.