Disclosed are methods of enhancing cognitive impairment in a patient wherein the cognitive impairment is due to ADDL neurotoxicity. The catalyst may be combined with a fluoropolymer having nitrogen-containing cure-sites to form a curable composition that is useful for preparing fluoroelastomer compositions. A switching device is used for switching the load limiting device. In a preferred embodiment, maleic anhydride initially serves as a catalyst and subsequently enters into a cross-linking reaction during curing to form a poly.