A child-resistant closure includes a plastic inner shell having a base wall with a peripheral skirt, at least one internal thread segment on the peripheral skirt and a plurality of internal lugs on the base wall adjacent to the skirt. The wear-resistant composite composition comprises a ceramic compound and at least 50 volume %, based on the total volume of the wear-resistant composition, of an intermetallic nickel-aluminide chosen from the group consisting of NiAl and Ni3Al. A basic combustion residue derived from the metal oxyacid salt is neutralized by hydrogen chloride derived from the ammonium perchlorate, thereby substantially neutralizing combustion residue of the gas-generating composition. The antibody reagents specifically bind to the remnant of ubiquitin left on a peptide which as been generated by digesting or chemically treating ubiquitinated proteins. The automated system provides a fluid application system that can apply a precise and repeatable layer of fluid to an object.