Systems and methods to monitor pump cavitation are disclosed. The base wall is outside a first closed line segment which defines an inside of the inner surface of the tube and is inside a second closed line segment which is similar to the first closed line segment and encloses the first closed line segment with a gravity center of the second closed line segment coincident with a gravity center of the first closed line segment. The estimated perforating time is a time interval expected to be necessary for a perforation to be produced by the heat of the heat source and to be enlarged to a desired size as a final size as measured from the time at which supply of energy to the heat source is started. Consequently, the range of the oscillation frequency is increased. The invention therefore provides a composition comprising: a Neisserial antigen; a CpG oligonucleotide; and a biodegradable polymer microparticle. The magnetic powder is composed of an alloy composition represented by Rx100-x-y-zByMz maxkJm3 of the bonded magnet at a room temperature satisfies the relationship represented by the formula max\u03c12\xd710\u22129 Jm3g2 2.