The invention includes methods of forming patterned reticles. The controller circuit is operable to detect a ventricular tachycardia heart rhythm from the cardiac signal, measure an amount of time the heart signal is one of inside or outside of an effective amplitude band, and initiate ATP therapy if the measured amount of time is less than a threshold amount of time. It also includes a continuous membrane being arranged to the container and about a valve axis through the wall opening. The directional control assembly further includes a second plate secured to and adapted for slidable movement with respect to the hopper and the first plate. The method applies the mixture to adhere to a tissue region. The actuator comprises a component configured to move in a direction to an actuator position so as to cause corresponding rotation of the valve to a valve position in response to electrical operation of the actuator.