Compositions and methods useful for the removal of organic substances from substrates, for example, electronic device substrates such as microelectronic wafers or flat panel displays, are provided. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, sulfur or nitrogen attached to a methylene group, to which is further attached a sulfur, nitrogen or CH2 group. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease. The centering pins are, in relation to the grooves, designed such that each centering pin rests only on one flank of the associated groove. If a channel having the desired attribute is found during the first or second scan, the scan may terminate. The method further includes assembling a detector comprising the scintillator crystal in an assembly environment comprising an inert gas.