There are described novel substituted tylosin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. If the system is modular, the navigation element may be an insertable module thereof andor include a lumen to receive another insertable module. Below the power supply line, a complete isolation portion reaching an upper surface of an insulating film is formed in the isolation insulating film. Further, by using the conductive layer as a power source layer, the capacity of supply of power to an IC chip can be improved.