The invention provides for methods of modifying immunodominant epitopes on polypeptides, preferably polypeptides intended for therapeutic use. In an embodiment, the method includes positioning a semiconductor topography against a carrier plate with a raised section. Alternatively, the surface region has more halogen or chalcogen in the elemental composition. Furthermore, the apparatus and method implements and system for recycling cleaning solution for continuous treatment of the pipeline. The X-Y receiver searches for all instances of each symbol and combines all instances.