The present invention relates to substituted spiro compounds, to processes for preparing them, to medicaments comprising these compounds and to the use of these compounds for producing medicaments. A counter, referred to herein as a \u201cfrequency counter,\u201d is incremented during those time intervals an overload condition is detected and is decremented during those time intervals an overload condition is not detected. The horizontal pressing portions are formed in at least three positions in a circumferential direction at regular intervals or at four positions at an interval of approximately 90\xb0 in the circumferential direction. The fastener apparatus further comprises a fastening tool supported by the frame and moveable to the fastener position. The polyamide oligomers are heterobifunctional allowing the attachment of other suitable ligand compounds.