The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate andor inhibit abnormal cell proliferation. The steps include arranging optical fibers within a catheter, the catheter having a tip whose length is at least 1 cm and whose diameter of less than 1 millimeter, connecting an excimer laser to the optical fibers; and delivering laser energy from the excimer laser in excess of a fluence of 60-mJmm2 at 40 Hertz through the optical fibers. Adjacent to the phase shift and transmission control layer is an optically transparent material, comprising a groove located within the line, wherein the groove comprises a region of reduced thickness in the optically transparent material. In embodiments, fine adjustments are made to the output signal level of the upstream amplifier by varying a bias current of the DAC. Each of the first ends is connected to a corresponding one of the second ends by a corresponding one of the modified reflection surface profiles.