The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest andor apoptosis of neoplastic cells, andor inhibiting histone deacetylase by administration of pharmaceutical compositions comprising potent HDAC inhibitors. At least one of the select andor column select transistors is a low threshold voltage device. All lens elements constituting the first lens unit G1 are arranged with intervening air spaces between one another. The switch is located on the joystick such that the operator can manipulate the switch without having to remove his hands from the joystick.