A method and apparatus for securing a printing plate on a plate cylinder is disclosed. Trimming logic values are produced in response to a clock signal that is applied to the device in a trimming mode. The first strands may have a substantially vertical orientation and the second strands may have a rearwardly-angled orientation. The regions of varying flow volume enable variable cooling across the fuel cell stack, thereby enabling a constant temperature to be achieved across the fuel cell stack. Other methods for converting cancer processive telomerase to the more benign non-processive telomerase include partially cleaving the telomerase RNA.