Small cyclic peptides of the formula X1-X2-X3-X4-X5-X6-X7-R1 comprising 7-12 amino acid residues are provided. The cylindrical part extends over substantially a half circumference of an equatorial edge of the hemispherical part and is defined by a plane inclined on the equatorial plane. The device also includes a first curved die at the distal end of the device for imparting a looping configuration to portions of the flexible elongated element exiting the distal end of the device, and a second curved die at the distal end for receiving the looped flexible elongated element as it returns to the distal end of the device.