An input signal is time-frequency transformed, then the frequency-domain coefficients are divided into coefficient segments of about 100 Hz width to generate a sequence of coefficient segments, and the sequence of coefficient segments is split into subbands each consisting of plural coefficient segments. According to the invention, the four mobile elements are mounted pivoting on the movement about second, third, fourth and fifth axes arranged on a straight line perpendicular to them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations.