A feature of the present invention includes a device having a display controller for controlling a display position of the pointer on the display screen, a displacement detector for detecting a displacement of the device itself, and a pointer mover for moving the pointer on the display screen based on the detected displacement of the device itself. The semiconductor memory device may include a flash memory cell array unit and a mask read-only memory cell array unit which are formed in a single memory block without an isolation layer for separating the two units. The main controller detects the address information stored in the memory upon receiving the transmission request of the address information from the sub-controller, and transmits the detected address information to the sub-controller. The losses in actual usable space are determined for a building and an inefficiency factor is calculated based on these losses. The method includes sensing the ventricular wall acceleration signal during at least during a sensing window corresponding to a ventricular filling phase. The MLN 51 gene and protein is closely related to the development of rheumatoid arthritis and serve as biomarker and therapeutic target for rheumatoid arthritis, particularly chronic synovitis.