Process for hydrocyanating a substrate selected from 2-, 3-, or 4-pentenenitrile andor 2-methyl-3-butenenitrile or mixtures thereof by contacting the substrate with HCN in the presence of a zero-valent nickel catalyst and a promoter that is obtained as a byproduct of titanium ore chlorination. The method further includes providing, on the substrate, a series of wall structures for forming one or more cavities there between. lividans of the P450 monooxygenase OleP produces 8,8 a-dihydroxy-6-deoxyerythonolide B and other derivatives that are precursors to important macrolide antibiotics.