A cooling fan has a ring-shaped metal spacer, a boss of substantially a cylindrical shape made of a synthetic resin that is molded integrally with the spacer as an insert and lural blades that extend outwardly from the boss. A spectacle lens designing method in which an eye motion is taken into consideration, and which uses, as an evaluation function regarding visual acuity constituting a merit function which is used in optimization calculation, a visual acuity evaluation function derived in an ordinary manner from a visual acuity measured value V which is actually measured. The leading end position sensor detects a protruding amount of the subsequent printing sheet when the preceding printing sheet is fed by the first feeding roller. The second part of the doubled up mechanism includes a cylindrical cover having intermittent inner radial shoulders which are interlockable upon rotation of the cylindrical cover with radial flange shoulders positioned intermittently around the main radial flanges. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.