The liquid crystal display device includes a first substrate, a second substrate arranged in facing relation to the first substrate, and a liquid crystal layer sandwiched between the first and second substrates. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to the glucocorticoid receptor can be used in methods of increasing the therapeutic response to electroconvulsive therapy. The pressing step is performed simultaneously with the twisting step. According to another embodiment, an integrated circuit includes a plurality of processor cores and processing circuitry. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.