A mechanism is provided for isolating application-specific data in an environment where multiple applications share a same user account. The apparatus includes a cylinder having an internal portion, a rod operatively positioned within the internal portion of the cylinder, a first bearing operatively positioned about rod; a second unidirectional bearing operatively positioned about the rod and a motion program for selectively inputting incremental radial motion to the rod. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed:where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and \u2014CR13, where R13 is a C1 to C6 alkyl or an aryl group.