An optical recording medium for accurately deriving the address information or the disc rotation control information despite narrow track pitch and for recording signals to a high density, and a method and apparatus for recording andor reproducing such optical recording medium. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. The invention may also make use of a Filter-Keg in lieu of a Hot Fluid Tank allowing fermentation, conditioning and dispensing from a single replaceable vessel. A position of the upper guide member 12 is vertically changed to follow up lower surface positions of the eccentric cams 22, thereby making the distance between the pair of guide members 12 and 13 variable. Over each design iteration, the constraints are tightened until a complete, global, topological solution is found.