Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. A machine within the media editing system may be configured to receive a render request for generation of a media frame, determine whether a client device is to generate the media frame, and initiate generation of the media frame. A joint extends between the connector and a rotatable tube. A particular application is provided for medium-voltage, high-current circuit breakers. The LED drivers andor LED driver controllers may be especially suitable for LEDs used to provide lighting for high-speed visions systems. The centerboard has first and second opposite sides.