The present invention is directed to methods and agents that are useful in the prevention and amelioration of signs and symptoms associated with neuropathic conditions. Also provided are methods of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising contacting a sample from the individual with a peptide analogue and determining in vitro whether T cells in the sample recognize the peptide analogue. The oxygen vacancy profile alters an absorption profile within the optical medium. The receiver can communicate to a transmitter in the system a request for additional channel estimation resources. The active area defined by the switchable cells includes at least a first switchable region having a specific gate-drain capacitance which is different to a specific gate-drain capacitance of a second switchable region. The expansion plug has at least one eccentric geometry, so that an expansion of the expansion sleeve can be achieved by a rotational movement of the anchor bolt, especially around the longitudinal axis as the axis of rotation.