Etoposide analogs such as 4\u2032-O-demethyl-4\u03b2-4\u2033–anilino-4-desoxy-podophyllotoxin and 4\u2032-O-demethyl-4\u03b2-4\u2033–anilino-4-desoxypodophyllotoxin are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same. A blade cutting edge of the wide angle arrowhead maintains an interior angle relationship to the centerline of an arrow shaft where such relationship can be fashioned to have one interior angular relationship within a specified angular range. The reduced power supply voltage is held equal to the reference voltage by adjustment of the voltage at an internal control node. Upon identifying updated versions, the application downloads the updated versions and loads or reloads them into the runtime environment prior to initiating the main functionality of the application. Optional features include internal agitators for improving processing and screening, assisted drying of raw material by motor exhaust, and initial pre-screening of foreign material.