The invention relates to a device and method for melt spinning and cooling a filament bundle. Flexible limbs extend laterally from the stock assembly. A second 2D array includes registers for storing image values corresponding to a macroblock. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed.