The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 activity; and pharmaceutical compositions comprising the compounds. First, in response to a query, the system presents a ranked list of query results to a user. Release of the reverse gear and associated rapid acceleration of the vehicle in drive is accomplished by a modular transmission brake adapter using the existing electronic automatic transmission control system without extensive modification thereto. If the sending device identification information is available at a given communication device, it is received from the communication device.