A policy engine generates configlets that are vendor-neutral, vendor-specific or both, based on a selected target level and a selected devicedevice group. Accordingly, it is difficult to obtain a thin film having the improved properties in both the surface morphology and the step coverage. In some embodiments, the frame and lenses have a wrap-around design to reduce air flow in the vicinity of the eyes. For example, two separate overlay patterns that are mirror images of each other may be used. The methods generally involve determining a normalized expression level of an EMX2 gene product, which correlates with prognosis and likelihood of survival.