The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. The probes are connected to measuring resources and resources for processing the electrical signals emitted by the probes. The first to Nth current driving portions operates the switching portions corresponding to magnitudes of the driving currents detected by the current detecting portions respectively. The dummy pattern prevents stress caused by dicing from being concentrated on an insulation film in the dicing region, thereby minimizing a crack waste. More particularly, an endless toothed belt having an abrasion- and noise resistant cover element, which comprises at least one friction-modifying constituent and at least one binder constituent. The longitudinal axis of each of the at least one array of transducers is oriented at an angle relative to the line oriented orthogonally to the intended direction of tape travel thereacross, the angle being between 0.