Embodiments of the present invention provide fine grain concurrency control for transactions in the presence of database updates. The rate controller assigns a quantization parameter for video data in a picture in response to complexity indicators indicative of spatial complexity, motion complexity andor bits per pel of the picture. The file includes an application identifier corresponding to the device identification. The recipient client receives and identifies the secure package identifier and the encoded transfer data, receives from a second user a user identifier, and communicates the user identifier and the secure package identifier to the main server, which communicates them to the key server. Further disclosed are pharmaceutical compositions comprising HIF-1\u03b1 prolyl hydroxylase inhibitors useful in treating diseases, conditions, andor syndromes related thereto the activity of HIF-1\u03b1.