A flexible pneumostoma management device maintains the patency of a pneumostoma while controlling the flow of material through the pneumostoma. The honeycomb body is partially wetted and then coated. Each specific node path segment N for the communication path is selected upon ensuring that it can be protected in the network by a node backup path satisfying the initial user’s requirements. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor blockade is beneficial.