A multimedia production and distribution system collects or assembles a media production from a variety of sources, including television stations and other media hosting facilities. Methods of identifying inhibitors of cholesterol uptake and related pharmaceuticals and methods of treatment also are described. A header space for supplying a second fluid is provided to the outer circumference of a wall surface of the internal cylinder in contact with flow separation areas which are formed along downstream surfaces of the swirl-generating stator as the first fluid runs into the swirl-generating stator.