An integrated system and method for treatment of various diseases, including psychiatric, mental and brain disorders, which preferably combines personalized non-invasive neuronal brain stimulation together with appropriate personalized cognitive training, and which iteratively fine-tunes this treatment by monitoring specific cognitive and brain functions in response to the treatment. A sputtering target of silicon has a metal plate positioned close enough to the sputtering site on the target to permit metal atoms to be dislodged by sputtered silicon, and deposited with the silicon to form an alloy. The electrochemical laminates are assembled in a way that prevents air entrapment between the electrochemical laminates. The thermally conductive bumps are bonded to a circuit board, and thereby reduce contact area between the heat-dissipating device and the circuit board, without forming of voids or popcorn effect during a solder-reflow process. The composition comprises soy phytoestrogens, including genistein, daidzein, glycitein, biochantin A, and derivative thereof, actin cytoskeleton reorganization inhibitors, such as Cytochalasin D, and PTK inhibitors, in combination with ECM proteins, such as laminins and type IV collagens, or their derivatives. The system provides for reduced X-ray dose to the patient associated with that part of the X-ray beam associated with a peripheral portion of the captured images although temporal, and in some embodiments spatial, resolution is reduced in the peripheral portion of the image.