A method includes receiving first control data at a proxy controller from a proxy remote control signal receiver device. The guidewire can comprise an integrated CMUT-on-CMOS ultrasound transducer array to provide 3D imaging of vasculature and other tissue. Depressing the dome by pushing downward on it causes the lower layer of the first compartment to be ruptured without cutting or rupturing the upper layer, releasing the first component into the second compartment. More accurate synchronization may be accomplished by adding more stages, by utilizing light out of a nonlinear laser in which the two beams are crossed, or by utilizing heterodyne beats of the two laser beams.