A therapeutic heated pocket and method of use in accordance with the present disclosure generally comprises an outer covering, edge trim, baby-dry material, insulation material, headliner material, heating coil, heating element, power cord and power adjustment controller. The metallic body includes a tapered leading edge having an interface surface and an opposite, free surface. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells. The divider divides a first signal to provide a second signal with a slew rate lowered from the slew rate of the first signal and the gate passes the second signal when commanded by the first signal to thereby generate a clock signal.