Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. A first portion of a first fiber-optic cable containing the first optical fiber does not contain any part of the second optical fiber, such that there are independent paths from the switching node to the passive remote node. The controller may regulate the module to perform a backup operation when a power saving mode begins and to interrupt the power after the backup operation is completed. Alternatively, the slurry includes colloidal silica, aluminum or aluminum-silicon, and an organic stabilizer such as glycerol. The correction parameter can be optimized by deriving a correction parameter for each of a multitude of distinct subsequences of one or more runs. The plurality of computers includes a server and a plurality of clients, and the server is a web server with the plurality of clients each further including a browser.