Compositions and methods for diagnosing, treating andor preventing cancers characterized by CDH17 overexpression based on the detection of CDH17 or the use of CDH17 as a target for therapeutic intervention or prophylactic intervention are provided. A species, such as hydrogen or helium, is implanted into a substrate to form a layer of microbubbles. The chelating agent is present in a sufficient amount to ensure that in the deposited pretreatment coating on the metal substrate the average total atomic % of copper to atomic % of zirconium is equal to or less than 1. The information display device can be configured such that it superimposes, for example, shooting information and focus points on the image. The lasers can have different central frequencies which can also be individually tunned using offset modules in the phase-responsive devices.