A method and system for transparently recovering from a coupling facility failure are disclosed. A system and method for providing an in-place editing surface for a component such as a file, document or control, within the context of the hosting file is described. The method and system serves as a management tool for the driver and reference signals for a train cruise control or autopilot system. A first load circuit is electrically coupled to the differential input circuit. Also provided are methods of treatment with antagonists of IL-17, IL-19, andor IL-23.